1-(3,4-Dichlorophenyl)piperazine → HCID 10401773, compound

HRID 555306Notes

Reaction equation

HRID 555306 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[O:15]1[CH2:17][CH:16]1[CH2:18]OS(C1C=CC=C([N+]([O-])=O)C=1)(=O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:18][CH:16]3[CH2:17][O:15]3)[CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 936011-(3,4-Dichlorophenyl)piperazineHCID 286836(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate

Product 1

HCID 10401773HCID 10401773, compoundYield 97%

Procedure

The same method as employed in the preparation of Intermediate 1 but starting from 1-(3,4-dichloro-phenyl)-piperazine) and 3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after Biotage chromatography the title compound as a yellow oil in a 97% yield.

Sources & evidence

ORD record
ord-32bcbe8557174bc39eff30b160f21359
Source dataset
uspto-grants-2011_11
Patent number
US08053436B1

Reaction notes

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