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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555308Generated: October 25, 2026

(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-Oxiranylmethyl-4-(3-phenyl-propyl)-piperazine

https://huagongshe.com/reaction/555308

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 286836—
Reactant1-(3-Phenylpropyl)piperazineHCID 796534—
Product(+/-)-1-Oxiranylmethyl-4-(3-phenyl-propyl)-piperazineHCID 1781051980%

Reaction Steps

The same method as employed in the preparation of Intermediate 1 but starting from 1-(3-phenylpropyl)-piperazine and 3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after Biotage chromatography the title compound as a yellow oil in a 80% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053436B1
Source datasetuspto-grants-2011_11
ORD IDord-a7606830c6ef40fa8c593f3e47f355cc
Source noteuspto-grants-2011_11