3,6-Dichlorocarbazole → HCID 66742605, compound

HRID 555319Notes

Reaction equation

HRID 555319 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][C:10]([Cl:15])=[CH:9][CH:8]=3.[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH:30]2[CH2:32][O:31]2)[CH2:25][CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:24][CH2:25][N:26]([CH2:29][CH:30]([OH:31])[CH2:32][N:6]2[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:14][C:13]=3[C:12]3[C:7]2=[CH:8][CH:9]=[C:10]([Cl:15])[CH:11]=3)[CH2:27][CH2:28]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 2364873,6-DichlorocarbazoleHCID 15491146tert-Butyl 4-[(oxiran-2-yl)methyl]piperazine-1-carboxylate

Product 1

HCID 66742605HCID 66742605, compoundYield 74%

Procedure

The same method as employed in the preparation of Example 1 but starting from 3,6-dichloro-9H-carbazole and (±)-4-oxiranylmethyl-piperazine-1-carboxylic acid tert-butyl ester gives after flash chromatography the title compound as a white foam in a 74% yield.

Workup

  1. customThe same method as employed in the preparation of Example 1

Sources & evidence

ORD record
ord-620d2873c17344c9afae326f7551af2f
Source dataset
uspto-grants-2011_11
Patent number
US08053436B1

Reaction notes

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