Phenylboronic Acid → HCID 57948698, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 1 (7 mg, 0.018 mmol), benzeneboronic acid (2.6 mg, 0.021 mmol) and tetrakis(triphenylphosphine)palladium (2 mg, 0.002 mmol) in DMF (2 mL)/aqueous 2 N sodium bicarbonate solution (0.5 mL) is stirred for 20 minutes in a microwave reactor at 130° C. After being cooled to room temperature, the reaction mixture is extracted with ethyl acetate (3×10 mL). The combined organic phases are dried over sodium sulfate and concentrated in vacuo. The residue is subjected to flash column chromatography (silica gel, 30% EtOAc in hexanes) to afford compound 29 (2.3 mg, 33%) as white solid.

Provenance & Evidence