HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Carbamic acid, (1-methyl-4-piperidinyl)-, 1,1-dimethylethyl ester (9CI)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Product | Carbamic acid, (1-methyl-4-piperidinyl)-, 1,1-dimethylethyl ester (9CI) | HCID 18738310 | 79.4% |
Reaction Steps
The procedure of Preparation Example (1-iii-1) was repeated except for using t-butyl-piperidin-4-ylcarbamate (1.67 g, 8.4 mmol) obtained in Preparation Example 1-ii and iodomethane as the starting materials, to obtain 1.43 g of the title compound as pale yellow oil (yield 79.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053435B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0ac8d2faffba435d833e1f1aab4c3ac9 |
| Source note | uspto-grants-2011_11 |