Lithium hydroxide, monohydrate → HCID 66986854, compound

Participants

Reaction Steps

Methyl (E)-4-(3-(1-methylpiperidin-4-ylamino)-2-((naphthalen-1-yloxy)methyl)-3-oxo-prop-1-enyl)benzoate (300 mg, 0.65 mM) obtained in Example (1-1-1) was dissolved in water (1 ml), and lithium hydroxide monohydrate (LiOH.H2O) (82 mg, 1.95 mM) was added thereto. The resulting mixture was stirred at room temperature for 10 mins, and further stirred at 50° C. for 3 hrs. After the completion of reaction, the reaction mixture was cooled to room temperature and ice water was poured thereinto, followed by removing the solvent under reduced pressure. Then, the resultant was cooled to 5, acidified with 2N hydrochloride solution to pH 4, extracted with chloroform/methanol (4/1) 3 times. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain 281 mg of the title compound (yield 97%).

Provenance & Evidence