Trifluoroacetic acid → HCID 24898137, compound

Participants

Reaction Conditions

Reaction Steps

(E)-4-(3-(1-Methylpiperidin-4-ylamino)-2-((naphthalen-1-yloxy)-methyl)-3-oxoprop-1-enyl)-N-(tetrahydro-2H-pyran-2-yloxy)benzamide obtained in Example (1-1-3) (333 mg, 0.61 mM) was dissolved in methanol (5 ml) and the resulting solution was cooled to 0° C. To the resulting solution, trifluoroacetic acid (0.23 ml, 5 eq.) was slowly added, and the resultant was reacted at room temperature for 18 hrs. After the completion of reaction, the solvent was removed under reduced pressure. The residue thus obtained was purified with a silica gel column chromatography (eluent: ethyl acetate/n-hexane=2/1) to obtain 250 mg of the title compound as a white solid (yield 89%).

Provenance & Evidence