Diethyl Ether → Methyl 6-oxohexanoate

Participants

Reaction Steps

Pyridinium chlorochromate (16.27 g, 75.48 mM) was dissolved in dichloromethane (140 ml), and a solution of methyl 6-hydroxy-hexanoate (10.03 g, 68.61 mM) obtained in Preparation Example 2-1 dissolved in dichloromethane (20 ml) was added dropwise thereto over 30 min. The resulting mixture was stirred at 25˜30° C. for 2 hrs. After the completion of reaction, the reaction mixture was diluted with ethyl ether, filtered and concentrated under reduced pressure. The residue thus obtained was subjected to a silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/4), to obtain 5.77 g of the title compound (yield 59%).

Provenance & Evidence