Trifluoroacetic acid → HCID 24899028, compound

Participants

Reaction Steps

(Z)-8-(2-morpholinoethylamino)-7-((naphthalen-1-yloxy)methyl)-N-(tetrahydro-2H-furan-2-yloxy)oct-6-enamide (63 mg, 0.09 mmol) obtained in Example (3-1-3) was dissolved in methanol (1.5 ml), and trifluoroacetic acid (0.04 ml, 0.45 mmol) was slowly added thereto at room temperature. The resulting mixture was reacted for 8 hours to conduct a deprotection reaction of THP. After the completion of reaction, the reaction solution was concentrated under reduced pressure. The residue thus obtained was purified by a preparative HPLC to obtain 21 mg of the title compound as pale orange oil (yield 53%), which was used in the subsequent analysis.

Provenance & Evidence