Tetrahydrofuran → HCID 11598087, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-trifluoromethoxy-1-methyl-aniline (32 mg, 0.17 mmol) in THF (1 mL) was slowly added 1c (40 mg, 0.14 mmol). The reaction was stirred 18 h at 60° C. and concentrated. The residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluent to afford 105a (36 mg, 45%). [M+H]+=476.08.

Provenance & Evidence