反应详情

温度

0 °C

A solution of 136d (16.28 mg, 0.0600 mmol) in anhydrous DCM (1.0 mL) was added dropwise to a cold solution of thiocarbonyl diimidazole (21.39 mg, 0.1200 mmol) in anhydrous DCM (0.50 mL). The reaction was stirred at 0° C. for 1 h and then warmed to rt with stirring for 2 h. The mixture was concentrated down and the residue was flushed through a plug of silica gel with 10% EtOAc in hexanes. Concentration of the eluent afforded 136e.

1. temperaturewarmed to rt
2. stirringwith stirring for 2 h
3. concentrationThe mixture was concentrated down
4. customthe residue was flushed through a plug of silica gel with 10% EtOAc in hexanes