3-Benzyloxy-pyrid-2-ylsulfonamide → 3-Hydroxypyridine-2-sulfonamide

HRID 55546Notes

Reaction equation

HRID 55546 reaction equation
C([O:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 199579343-Benzyloxy-pyrid-2-ylsulfonamide

Product 1

HCID 199579383-Hydroxypyridine-2-sulfonamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 263.7 g of 3-benzyloxy-pyrid-2-ylsulfonamide in 2.5 of methanol is hydrogenated with the addition of 26 g of 5% Pd/C catalyst. After 23.8 of hydrogen have been absorbed, the catalyst is filtered off. After evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide remains in the form of a crystalline mass. Melting point 162°-164° C.

Workup

  1. customAfter 23.8 of hydrogen have been absorbed
  2. filtrationthe catalyst is filtered off
  3. customAfter evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide

Sources & evidence

ORD record
ord-08f62883e8e445e6bd985de2e4e3236d
Source dataset
uspto-grants-1997_04
Patent number
US05625071

Reaction notes

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