Acetic acid, 2-(4-formylphenoxy)- → 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Acetic acid, 2-(4-formylphenoxy)-	HCID 89177	—
Reactant	2-Amino-4,6-dimethoxybenzamide	HCID 20349016	—
Reactant	2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one	HCID 136038000	—
Product	2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid	HCID 136038018	21%

Reaction Steps

2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid was synthesized from 2-amino-4,6-dimethoxy-benzamide and (4-formyl phenoxy)acetic acid, using the method described for 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one. 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid (135 mg, 21%) was isolated as an off-white solid. Selected data: MS (m/z): 357.04; MP 287-290° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08053440B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-0caacbde8dc94d8da7a2cd24dd32c886
Source note	uspto-grants-2011_11