HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Di-tert-butyl-4-hydroxybenzaldehyde → 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Di-tert-butyl-4-hydroxybenzaldehyde | HCID 73219 | — |
| Reactant | 2-Amino-4,6-dimethoxybenzamide | HCID 20349016 | — |
| Reactant | 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one | HCID 136037998 | — |
| Product | 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one | HCID 136037991 | 41% |
Reaction Steps
2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 3,5-di-tert-butyl-4-hydroxybenzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (130 mg, 41%) was isolated as a light yellow solid. Selected data: MS (m/z): 411.17; MP 229.7-230.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053440B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-91948110fb464cefb72e4c0e0e386a02 |
| Source note | uspto-grants-2011_11 |