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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555474Generated: October 29, 2026

4-Methoxybenzaldehyde → 5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-one

https://huagongshe.com/reaction/555474

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethoxybenzaldehydeHCID 31244—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-oneHCID 13603796144%

Reaction Steps

5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 4-methoxy benzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-one (106 mg, 44%) was isolated as an off-white solid. Selected data: MS (m/z): 312.99; MP 276-277° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053440B2
Source datasetuspto-grants-2011_11
ORD IDord-5b4e560812504bd8bc01528cf43e9cc9
Source noteuspto-grants-2011_11