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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555483Generated: October 26, 2026

Anthranilamide → 2-(4-(Dimethylamino)naphthalen-1-yl)quinazolin-4(3H)-one

https://huagongshe.com/reaction/555483

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAnthranilamideHCID 6942—
Reactant4-Dimethylamino-1-naphthaldehydeHCID 608052—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(4-(Dimethylamino)naphthalen-1-yl)quinazolin-4(3H)-oneHCID 13603798669%

Reaction Steps

2-(4-(Dimethylamino)naphthalen-1-yl)quinazolin-4(3H)-one was synthesized from anthranilamide and 4-dimethylamino-naphthalene-1-carbaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(4-(Dimethylamino)naphthalen-1-yl)quinazolin-4(3H)-one (240 mg, 69%) was isolated as a pale yellow solid. Selected data: MS (m/z): 316.08; MP 224-226° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053440B2
Source datasetuspto-grants-2011_11
ORD IDord-cece9c8c08414761ad3a6070d6f2a77a
Source noteuspto-grants-2011_11