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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555485Generated: October 30, 2026

2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → HCID 136037972, compound

https://huagongshe.com/reaction/555485

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 248127—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
ProductHCID 136037972HCID 13603797246%

Reaction Steps

2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5,7-dimethoxyquinazolin-4(3H)-one (120 mg, 46%) was isolated as a yellow solid. Selected data: MS (m/z): 341.03; MP 307.5-309.6° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053440B2
Source datasetuspto-grants-2011_11
ORD IDord-c04856d693994b13b1cf3b43320e6e31
Source noteuspto-grants-2011_11