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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555489Generated: October 26, 2026

4-Dimethylamino-1-naphthaldehyde → 2-(4-(dimethylamino)naphthalen-1-yl)-6,7-dimethoxy-quinazolin-4(3H)-one

https://huagongshe.com/reaction/555489

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Dimethylamino-1-naphthaldehydeHCID 608052—
Reactant2-Amino-4,5-dimethoxybenzamideHCID 10867236—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(4-(dimethylamino)naphthalen-1-yl)-6,7-dimethoxy-quinazolin-4(3H)-oneHCID 13593903256%

Reaction Steps

2-(4-(Dimethylamino)naphthalen-1-yl)-6,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,5-dimethoxy-benzamide and 4-Dimethylamino-naphthalene-1-carbaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(4-(dimethylamino)naphthalen-1-yl)-6,7-dimethoxy-quinazolin-4(3H)-one (159 mg, 56%) was isolated as a white solid. Selected data: MS (m/z): 376.13; MP 235.5-236.5° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053440B2
Source datasetuspto-grants-2011_11
ORD IDord-e4f28ff28d9946ff8d0fd8bda47452b3
Source noteuspto-grants-2011_11