Methyl 4-(hydrazinecarbonyl)benzoate → HCID 178498004, compound

HRID 555600Notes

Reaction equation

HRID 555600 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:5]=[C:4]([CH3:17])[C:3]=1[C:18](=O)[CH3:19].[CH3:21][O:22][C:23]([C:25]1[CH:34]=[CH:33][C:28]([C:29]([NH:31][NH2:32])=[O:30])=[CH:27][CH:26]=1)=[O:24]>>[CH3:17][C:4]1[C:3](=[C:18]([NH:32][NH:31][C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([C:23]([O:22][CH3:21])=[O:24])=[CH:34][CH:33]=2)[CH3:19])[C:2](=[O:1])[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:5]=1

Participants

3

Reactant 2

HCID 596004Methyl 4-(hydrazinecarbonyl)benzoateHCID 178466980HCID 178466980, compound

Product 1

HCID 178498004HCID 178498004, compound

Procedure

From 1-(5-hydroxy-3-methyl-1-(3-trifluoromethylphenyl)-1H-pyrazol-4-yl)-ethanone and 4-methoxycarbonylbenzhydrazide, 59.9 mg of the desired product was obtained in the same manner as in Synthetic Example 4 as a yellow solid (yield 65%).

Sources & evidence

ORD record
ord-37a8fc38d2bc43e284df77d22b14c690
Source dataset
uspto-grants-2011_11
Patent number
US08053453B2

Reaction notes

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