Methyl 4-(hydrazinecarbonyl)benzoate → HCID 178498005, compound

HRID 555601Notes

Reaction equation

HRID 555601 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:17])[C:3]=1[C:18](=O)[CH3:19].[CH3:21][O:22][C:23]([C:25]1[CH:34]=[CH:33][C:28]([C:29]([NH:31][NH2:32])=[O:30])=[CH:27][CH:26]=1)=[O:24]>>[CH3:17][C:4]1[C:3](=[C:18]([NH:32][NH:31][C:29](=[O:30])[C:28]2[CH:33]=[CH:34][C:25]([C:23]([O:22][CH3:21])=[O:24])=[CH:26][CH:27]=2)[CH3:19])[C:2](=[O:1])[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:15])([F:16])[F:14])=[CH:9][CH:8]=2)[N:5]=1

Participants

3

Reactant 2

HCID 596004Methyl 4-(hydrazinecarbonyl)benzoateHCID 178466981HCID 178466981, compound

Product 1

HCID 178498005HCID 178498005, compound

Procedure

From 1-(5-hydroxy-3-methyl-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl)-ethanone and 4-methoxycarbonylbenzhydrazide, 58.9 mg of the desired product was obtained in the same manner as in Synthetic Example 4 as a yellow solid (yield 65%).

Sources & evidence

ORD record
ord-89e91617a9f4437f8df4d47cf304baeb
Source dataset
uspto-grants-2011_11
Patent number
US08053453B2

Reaction notes

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