4-Methoxycarbonyl-3-nitrobenzhydrazide → methyl 4-[[1-[1-(4-tert-butylphenyl)-3-methyl-5-oxopyrazol-4-ylidene]ethylamino]carbamoyl]-2-nitrobenzoate

Participants

Reaction Steps

DMF solution (2.0 mL) of 1-(1-(4-tert-butylphenyl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)-ethanone (54.5 mg, 0.20 mmol) and 4-methoxycarbonyl-3-nitrobenzhydrazide (47.8 mg, 0.20 mmol) was heated at 110° C. for 6 hours After removing solvent, the residue was purified by column chromatography to give the title compound (53.8 mg, 55%) as a brown solid.

Provenance & Evidence