HCID 136348805, compound → HCID 59707161, compound

HRID 555629Notes

Reaction equation

HRID 555629 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][N:9]=[C:10]([C:12]1[C:13](=[O:20])[O:14][C:15]([CH3:19])=[CH:16][C:17]=1[OH:18])[CH3:11]>C(O)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:13](=[O:20])[CH:12]([C:17](=[O:18])[CH2:16][C:15](=[O:14])[CH3:19])[C:10]([CH3:11])=[N:9]1

Participants

3

Reactant 1

HCID 136348805HCID 136348805, compound

Product 1

HCID 59707161HCID 59707161, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Heat at reflux for 1 hour 3-{1-[(2-fluoro-phenyl)-hydrazono]-ethyl}-4-hydroxy-6-methyl-pyran-2-one (0.045 g, 0.163 mmol) in acetic acid (0.3 ml). Add heptane (3 ml) and evaporate the mixture to dryness to give 1-[1-(2-fluoro-phenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]-butane-1,3-dione (0.045 g, 0.163 mmol). Use this material for the next step without further purification.

Workup

  1. temperatureHeat
  2. customAdd heptane (3 ml) and evaporate the mixture to dryness

Sources & evidence

ORD record
ord-e0eafc6706ab48508c5de2a8036bcb85
Source dataset
uspto-grants-2011_11
Patent number
US08053458B2

Reaction notes

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