Sodium Bicarbonate → HCID 178492070, compound

Participants

Reaction Steps

To (4-methoxyphenyl)-hydrazine hydrochloride (0.083 g, 0.48 mmol) in ethanol (5 ml) add sodium bicarbonate (0.067 g, 0.80 mmol) after which stir the mixture for 10 min. Add 1-[1-phenyl-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]-butane-1,3-dione (0.103 g, 0.40 mmol. The mixture was heated at reflux for 1.5 hours after which it was evaporated to dryness. Chromatography on silica gel, eluting with 50 to 100% ethyl acetate/heptane provided 0.071 g of the title compound.

Provenance & Evidence