Water → HCID 46193614, compound

Participants

Reaction Steps

Compound 34 (1.49 g, 0.004 mole) in 40 ml of 10% NaOH solution was heated under refluxing for 2 h. The progress of the hydrolysis reaction was monitored by TLC with ethyl acetate (EA). When the reaction was completed, the reaction mixture was poured into water to stop the reaction, and then was extracted with toluene. The aqueous layer was recovered, and acidified with 10% HCl solution, which was then extracted with EA. The organic layer was recovered and dried over MgSO4 and filtered. The solvent of the filtrate was evaporated under a reduced pressure, and the residue was then recrystallized from EA to afford compound 48 in brown columnar crystals (0.76 g). Yield: 78%; mp 234-237° C.

Provenance & Evidence