HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroquinone → 5-Hydroxy-2-oxo-3-(2,5-dimethylphenyl)-2,3-dihydrobenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroquinone | HCID 785 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-(2,5-Dimethylphenyl)-2-hydroxyacetic acid | HCID 277662 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Hydroxy-2-oxo-3-(2,5-dimethylphenyl)-2,3-dihydrobenzofuran | HCID 19702299 | — |
Reaction Steps
By the method described in GB 2068402A 2,5-dimethylmandelic acid (65 parts) was reacted with hydroquinone (33 parts) and 98% sulfuric acid (32 parts) and toluene (440 parts) to give 5-hydroxy-2-oxo-3-(2,5-dimethylphenyl)-2,3-dihydrobenzofuran (33 parts) which was isolated by crystallisation and chromatography. The 1Hnmr spectrum of the purified product was consistent with structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05625080 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-45c7af31fc014aff90a40c7b01b21a9c |
| Source note | uspto-grants-1997_04 |