反应详情

温度

50 °C

Methyl 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylate (64.3 g) was dissolved in ethanol (1100 mL). To this solution, a 1 mol/L aqueous solution of sodium hydroxide (1000 mL) was added and the mixture was stirred at 50° C. for 1 hour. Ethanol in the mixture was evaporated under reduced pressure and the residue was washed with diethylether (500 mL), followed by addition of concentrated hydrochloric acid to adjust the pH to acidic (pH 1). The resulting crystals were filtrated, washed with water, and dried under reduced pressure to give 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylic acid (56.1 g).

1. customEthanol in the mixture was evaporated under reduced pressure
2. washthe residue was washed with diethylether (500 mL)
3. additionfollowed by addition of concentrated hydrochloric acid
4. filtrationThe resulting crystals were filtrated
5. washwashed with water
6. customdried under reduced pressure