HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → (2S,4S)-1-(2-Chloroacetyl)-4-fluoropyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile | HCID 21090395 | — |
| Reactant | 2-Pyrrolidinecarboxamide, 4-fluoro-, hydrochloride (1:1), (2S,4S)- | HCID 45158917 | — |
| Product | (2S,4S)-1-(2-Chloroacetyl)-4-fluoropyrrolidine-2-carbonitrile | HCID 57518632 | — |
Reaction Steps
According to the production process of (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile described in WO 02/38541 pamphlet, (2S,4S)-4-fluoropyrrolidine-2-carboxamide hydrochloride (5.00 g) and chloroacetyl chloride (2.60 mL) were used to obtain (2S,4S)-1-(2-chloroacetyl)-4-fluoropyrrolidine-2-carbonitrile (4.96 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053465B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-e116ca2ca40c4176baaaca2d6564a690 |
| Source note | uspto-grants-2011_11 |