HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile → (2S,4S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile | HCID 21090395 | — |
| Reactant | 2-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate | HCID 23149698 | — |
| Product | (2S,4S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 59383132 | 79.6% |
Reaction Steps
In a similar manner to Example 2, 2-tetrahydropyranyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (62.9 mg) and (2S,4S)-1-(2-bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile (53.1 mg) were used to obtain (2S,4S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (73.3 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053465B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-40e75e5697d24171888a21829162d0f7 |
| Source note | uspto-grants-2011_11 |