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(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile → (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile | HCID 11031276 | — |
| 反応物 | 2-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate | HCID 23149698 | — |
| 生成物 | (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile | HCID 59383148 | 67.8% |
反応手順
In a similar manner to Example 2, 2-tetrahydropyranyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (90.0 mg) and (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile (70.0 mg) were used to obtain (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonyl bicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (85.2 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08053465B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-79c1915061854ef5827bbf4e5faf53d4 |
| 出典メモ | uspto-grants-2011_11 |