HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 59383139, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 59383139 | HCID 59383139 | 74.5% |
Reaction Steps
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (20.0 mg) and 4-trifluoromethylbenzyl bromide (16.2 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(4-trifluoromethylbenzyl)oxycarbonyl bicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (22.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053465B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0aba5424d48f4f5d80900410e9a41986 |
| Source note | uspto-grants-2011_11 |