HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-methylpropane → HCID 59383136, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 59383136 | HCID 59383136 | 60.5% |
Reaction Steps
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (20.0 mg) and isobutyl bromide (9.3 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(2-methylpropyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (14.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053465B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-fefcba3bf59c4868aa0ed787766da36d |
| Source note | uspto-grants-2011_11 |