1-(Bromomethyl)-2-(trifluoromethyl)benzene → HCID 59383146, compound

Participants

Role	Name	HCID	Charge
Reactant	1-(Bromomethyl)-2-(trifluoromethyl)benzene	HCID 123057	—
Reactant	(2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile	HCID 57634365	—
Product	HCID 59383146	HCID 59383146	89.3%

Reaction Steps

In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and 2-trifluoromethylbenzyl bromide (25.4 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(2-trifluoromethylbenzyl)oxycarbonyl bicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (39.9 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08053465B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-448c0fc17b594d6cb67311e2dce0374d
Source note	uspto-grants-2011_11