HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Xylyl bromide → HCID 59383145, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Xylyl bromide | HCID 6992 | — |
| Reactant | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| Product | HCID 59383145 | HCID 59383145 | 86% |
Reaction Steps
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and 2-methylbenzyl bromide (18.9 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(2-methylbenzyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (34.1 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053465B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7294ab80d0e94d879663170b9c55363a |
| Source note | uspto-grants-2011_11 |