1-(2-Hydroxyethyl)piperazine → HCID 66986846, compound

Participants

Reaction Steps

2-piperazin 1-yl-ethanol (510 mg, 3.9 mmol) is dissolved in CH3CN (5 mL). N-(2-Bromoethyl)-phthalimid (995 mg, 3.9 mmol) and anhydrous K2CO3 (1.1 g, 7.8 mmol) are added at RT and then the reaction mixture is refluxed for 5 h. The reaction mixture is allowed to cool to RT again and the precipitated crude product is isolated by filtration. It is then purified by flash chromatography (SiO2; DCM/MeOH, gradient 1-5% MeOH) to give the title compound as a white powder.: M+H=304.1; HPLC: CtRet=1.73 min.

Provenance & Evidence