2-(Dimethylamino)ethanol → HCID 63081293, compound

HRID 555718Notes

Reaction equation

HRID 555718 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[CH3:11][N:12]([CH3:16])[CH2:13][CH2:14][OH:15]>>[NH2:7][CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][C:4]=1[O:15][CH2:14][CH2:13][N:12]([CH3:16])[CH3:11]

Participants

3

Reactant 2

HCID 79022-(Dimethylamino)ethanolHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 63081293HCID 63081293, compound

Procedure

The title compound is synthesized by coupling followed by reduction of 4-chloro-2-fluoro-benzonitrile and 2-dimethylamino-ethanol analogously to the preparation of Intermediate 113.1. colorless oil; ES-MS: M+=229.2; HPLC: AtRet=1.18 min.

Workup

  1. customAtRet=1.18 min.

Sources & evidence

ORD record
ord-b42561c6ceb1404cba2d7d7ebfcc6200
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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