Ethanolamine → HCID 63082313, compound

HRID 555720Notes

Reaction equation

HRID 555720 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[NH2:11][CH2:12][CH2:13][OH:14]>>[NH2:7][CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][C:4]=1[NH:11][CH2:12][CH2:13][OH:14]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 936554-Chloro-2-fluorobenzonitrile

Product 1

HCID 63082313HCID 63082313, compound

Procedure

The title compound is synthesized by coupling followed by reduction of 4-chloro-2-fluoro-benzonitrile and 2-amino-ethanol analogously to the preparation of Intermediate 113.1. colorless powder; ES-MS: M−=199.1; HPLC: AtRet=1.90 min.

Workup

  1. customAtRet=1.90 min.

Sources & evidence

ORD record
ord-3c7c60619e1c4cf582b925bcec325b28
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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