Aluminum(III) Chloride → HCID 66987441, compound

Participants

Reaction Steps

A mixture of Example 2 (101 mg, 0.18 mmol), AlCl3 (117 mg, 0.88 mmol) and LAH (33 mg, 0.88 mmol) in THF (2 mL) is refluxed. After completion the reaction mixture is quenched by sodium-potassium tartarate and neutralized by saturated aqueous NaHCO3. EtOA is added and the organic layer is washed with brine, dried over MgSO4 and evaporated in vacuo. Silica gel flash chromatography of the residue affords the title compound as a colorless powder; ES-MS: M+H=561.8: AtRet=3.74 min.

Provenance & Evidence