6-Chloro-1H-indole-2-carboxylic acid → HCID 66987630, compound

HRID 555725Notes

Reaction equation

HRID 555725 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([OH:13])=O)[NH:8]2)=[CH:4][CH:3]=1.[CH3:14][N:15]([CH3:21])[C@H:16]1[CH2:20][CH2:19][NH:18][CH2:17]1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[C:7]([C:11]([N:18]3[CH2:19][CH2:20][C@H:16]([N:15]([CH3:21])[CH3:14])[CH2:17]3)=[O:13])[NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 855846-Chloro-1H-indole-2-carboxylic acidHCID 7019156(3S)-(-)-3-(Dimethylamino)pyrrolidine

Product 1

HCID 66987630HCID 66987630, compound

Procedure

The title compound is synthesized by condensation of 6-chloro-1H-indole-2-carboxylic acid and dimethyl-(S)-pyrrolidin-3-yl-amine analogously to the preparation of Example 2 as a colorless solid; ES-MS: M+=292.2; HPLC: AtRet=3.15 min.

Workup

  1. customAtRet=3.15 min.

Sources & evidence

ORD record
ord-a42752a0b6d349fa8592db397db7368b
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

Loading…