Bromoacetonitrile → HCID 28399247, compound

HRID 555742Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.Br[CH2:16][C:17]#[N:18]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:16][C:17]#[N:18])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 81430N-(3-methoxyphenyl)piperazine

Product 1

HCID 28399247HCID 28399247, compound

Procedure

The title compound is synthesized by coupling of 1-(3-Methoxy-phenyl)-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a white solid; ES-MS: M+=232.2: AtRet=2.62.

Sources & evidence

ORD record: ord-f43fa7b85642416dbc7bba4b6e1e9f53
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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