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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555753Generated: October 30, 2026

4-(Chloromethyl)pyridinium chloride → HCID 66987720, compound

https://huagongshe.com/reaction/555753

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)pyridinium chlorideHCID 74570—
Reactanttert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylateHCID 6544479—
ProductHCID 66987720HCID 66987720—

Reaction Steps

The title compound is synthesized by coupling of (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester and 4-chloromethyl-pyridine HCl salt analogously to the preparation of Intermediate 193.2 as a white solid; ES-MS: M+=279.2: AtRet=2.84.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053457B2
Source datasetuspto-grants-2011_11
ORD IDord-1d15c6e99a3e44bb840cffe74b42a5a2
Source noteuspto-grants-2011_11