Bromoacetonitrile → HCID 86641791, compound

HRID 555757Notes

Reaction equation

HRID 555757 reaction equation
[CH2:1]([N:4]([CH2:11][CH2:12][CH3:13])[CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH2:2][CH3:3].Br[CH2:15][C:16]#[N:17]>>[CH2:11]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:15][C:16]#[N:17])[CH2:9][CH2:10]1)[CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 3824021N,N-dipropylpiperidin-4-amine

Product 1

HCID 86641791HCID 86641791, compound

Procedure

The title compound is synthesized by coupling of Dipropyl-piperidin-4-yl-amine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=224.3: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.80-2.75 (m, 2H), 2.40-2.30 (m, 5H), 2.15-2.05 (m, 2H), 1.65-1.60 (m, 2H), 1.50-1.30 (m, 6H), 0.90 (t, 6H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-4e75c051083d4c29acc07f67bbbc1262
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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