Bromoacetonitrile → HCID 86641793, compound

HRID 555761Notes

Reaction equation

HRID 555761 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.Br[CH2:13][C:14]#[N:15]>>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:13][C:14]#[N:15])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 280636844-(3-Methoxypropyl)piperidine

Product 1

HCID 86641793HCID 86641793, compound

Procedure

The title compound is synthesized by coupling of 4-(3-Methoxy-propyl)-piperidine (commercially available from ChemBridge Corporation) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=197.2; 1HNMR(DMSO-d6) 3.65 (s, 2H), 3.30 (t, 2H), 3.00 (s, 3H), 2.75-2.70 (m, 2H), 2.10-2.00 (m, 2H), 1.65-1.40 (m, 4H), 1.20-1.00 (m, 5H).

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-20a2371a90f7471b95974cfdd509ab0f
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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