Bromoacetonitrile → HCID 82126013, compound

HRID 555763Notes

Reaction equation

HRID 555763 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:14][C:15]#[N:16]>>[N:10]1([CH2:14][C:15]#[N:16])[CH2:9][CH2:8][CH:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 11395974-(4-Piperidyl)pyridine

Product 1

HCID 82126013HCID 82126013, compound

Procedure

The title compound is synthesized by coupling of 1,2,3,4,5,6-Hexahydro-[4,4′]bipyridinyl (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=202.2: CtRet=2.41.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-150da02f9b384a14ad8d6688c941fd0a
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

Loading…