Bromoacetonitrile → HCID 60676849, compound

HRID 555765Notes

Reaction equation

HRID 555765 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Br[CH2:16][C:17]#[N:18]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][N:12]([CH2:16][C:17]#[N:18])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 566605Piperazine, 2-pyridylethyl-

Product 1

HCID 60676849HCID 60676849, compound

Procedure

The title compound is synthesized by coupling of 1-(2-Pyridin-2-yl-ethyl)-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=231.2: CtRet=2.17.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-189c3150e85940a183f9c2551a7dc7c7
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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