Bromoacetonitrile → HCID 21991753, compound

HRID 555766Notes

Reaction equation

HRID 555766 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH:10]([CH3:14])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:16][C:17]#[N:18]>>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:16][C:17]#[N:18])[CH:10]([CH3:14])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 27275201-Benzyl-3-methylpiperazine

Product 1

HCID 21991753HCID 21991753, compound

Procedure

The title compound is synthesized by coupling of 4-Benzyl-2-methyl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=230.2: AtRet=1.86.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-fb758dfab08249779fcc4e0f69fa81be
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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