Bromoacetonitrile → HCID 86641795, compound

HRID 555767Notes

Reaction equation

HRID 555767 reaction equation
[CH2:1]([C:8]1([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:16][C:17]#[N:18]>>[CH2:1]([C:8]1([OH:14])[CH2:13][CH2:12][N:11]([CH2:16][C:17]#[N:18])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 981524-Benzyl-4-piperidinol

Product 1

HCID 86641795HCID 86641795, compound

Procedure

The title compound is synthesized by coupling of 4-Benzyl-4-hydroxy-piperidine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=231.2: AtRet=1.81.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-58f92762932747079b1e2a85bad4557c
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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