Bromoacetonitrile → HCID 86641796, compound

HRID 555768Notes

Reaction equation

[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[CH2:15][C:16]#[N:17]>>[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][N:5]([CH2:15][C:16]#[N:17])[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 963874-Phenylpiperidin-4-ol

Product 1

HCID 86641796HCID 86641796, compound

Procedure

The title compound is synthesized by coupling of 4-Hydroxy-4-phenyl-piperidine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=217.2: AtRet=1.51.

Sources & evidence

ORD record: ord-3d5db30ff9544a548e11e06ec766d6ee
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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