Bromoacetonitrile → (4-Benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-acetonitrile

HRID 555769Notes

Reaction equation

HRID 555769 reaction equation
[CH2:1]([N:8]1[CH2:15][CH2:14][NH:13][CH2:12][C:9]21[CH2:11][CH2:10]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:17][C:18]#[N:19]>>[CH2:1]([N:8]1[CH2:15][CH2:14][N:13]([CH2:17][C:18]#[N:19])[CH2:12][C:9]21[CH2:10][CH2:11]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11534BromoacetonitrileHCID 113900664-Benzyl-4,7-diazaspiro[2.5]octane

Product 1

HCID 86641797(4-Benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-acetonitrile

Procedure

The title compound is synthesized by coupling of 4-Benzyl-4,7-diaza-spiro[2.5]octane (which prepared in analogy to a published literature procedure (WO030828859)) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=242.2: CtRef=3.84.

Workup

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Sources & evidence

ORD record
ord-b99cb0d6916f496bb3f38b1a27801f3f
Source dataset
uspto-grants-2011_11
Patent number
US08053457B2

Reaction notes

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