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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555771Generated: October 25, 2026

Bromoacetonitrile → 2-[4-(2-Phenoxy-ethyl)-piperazin-1-yl]-acetonitrile

https://huagongshe.com/reaction/555771

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBromoacetonitrileHCID 11534—
Reactant1-(2-Phenoxyethyl)piperazineHCID 233187—
Product2-[4-(2-Phenoxy-ethyl)-piperazin-1-yl]-acetonitrileHCID 60698871—

Reaction Steps

The title compound is synthesized by coupling of 1-(2-Phenoxy-ethyl)-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=246.2: CtRet=4.31.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053457B2
Source datasetuspto-grants-2011_11
ORD IDord-62e3a69302d04d789bfe411f5188b9aa
Source noteuspto-grants-2011_11