Benzimidazole → 1H-benzimidazol-1-ylacetonitrile

HRID 555772Notes

Reaction equation

[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH:2]=1.Br[CH2:11][C:12]#[N:13]>>[N:1]1([CH2:11][C:12]#[N:13])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

Reactant 2

HCID 5798Benzimidazole

HCID 11534Bromoacetonitrile

Product 1

HCID 47367691H-benzimidazol-1-ylacetonitrile

Procedure

The title compound is synthesized by coupling of Benzimidazole and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless solid; ES-MS: M+H=158.0: CtRet=3.42.

Sources & evidence

ORD record: ord-94050b9383184e16b1c38fcaa60d520e
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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